Journal article
Role of orbitofrontal sulcogyral pattern on lifetime cannabis use and depressive symptoms
Y Chye, N Solowij, EP Ganella, C Suo, M Yücel, A Batalla, J Cousijn, AE Goudriaan, R Martin-Santos, S Whittle, CF Bartholomeusz, V Lorenzetti
Progress in Neuro Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Abstract
Orbitofrontal cortex (OFC) sulcogyral patterns are stable morphological variations established early in life. They consist of three distinct pattern types, with Type III in particular being associated with poor regulatory control (e.g., high sensation seeking and negative emotionality, low constraint), which may confer risk for earlier onset of cannabis (CB) use and greater use in later life. The OFC sulcogyral pattern may therefore be a stable trait marker in understanding individual differences in substance-use vulnerability and associated affective disturbances in users. In a large multisite cross-sectional study, we compared OFC pattern type distribution between 128 healthy controls (HC)..
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Awarded by University of Melbourne
Funding Acknowledgements
Original data collection was supported by the Netherlands Organisation for Scientific Research-Health Research and Development, ZON-Mw [AG, grant #31180002]; an Amsterdam Brain Imaging Platform grant [JC]; Plan Nacional sobre Drogas. Ministerio de Sanidad y Politica Social [RMS, grant PNSD:2011/050 and SGR:2014/1114]; the Clive and Vera Ramaciotti Foundation for Biomedical Research [NS]; the Schizophrenia Research Institute with NSW Health [NS]; and the National Health and Medical Research Council (NHMRC) of Australia Project Grant [NS, #459111]. MY was supported by a National Health and Medical Research Council of Australia Fellowship [App#1117188] and the David Winston Turner Endowment Fund. EPG was supported by the University of Melbourne and CRC for Mental Health PhD top-up scholarship.